System That Controls Bone Development, Function Discovered


Scientists have discovered a system that manages the development and function of plate-like nanocrystals that play a crucial function in bone composition. The research study is released in the journal Biomaterials.

Bone is made up of protein collagen and mineral in the form of plate-like nanocrystals.

Previous research study has actually shown that the mineral crystallites play a vital role in proper bone function and physiology.

Their nanometer size renders them nearly flawless, which contributes to bone strength. Though scientists have actually known that nanocrystal size and morphology are crucial to the proper mechanical and physiological performance of bone, the system that controls these homes has actually been uncertain.

“Our research suggests, for the first time, that a chemical substitute, in absence of protein or other organic substances, affects the crystallite morphology of bone mineral,” said co-author Dr. Arun Nair, assistant professor of mechanical engineering at the University of Arkansas, Fayetteville.

“These are nanometer-sized crystallites, but still, the finding provides a much better understanding of the processes that control size and shape of particles that make up bone.”

Mimicking biochemical procedures, Dr. Nair and his colleagues from the United States, France and the United Kingdom manufactured apatite nanocrystals with carbonate.

Apatite is a group of phosphate minerals,” the researchers explained.

“The nanocrystals exhibited morphologies similar to those seen in natural bone mineral.”

The team’s discovery could result in the production of an artificially produced biomaterial to change bones.


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